Persistent URL of this record https://hdl.handle.net/1887/44297
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- Title page_Table of contents
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- General discussion and prospects
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Responding to environmental cues : the adaptive qualities of chromatin compaction proteins
The effective volume occupied by the genomes of all forms of life far exceeds that of the cells in which they are contained.
Therefore, all organisms have developed mechanisms for compactly folding and functionally organizing their genetic material. H-NS, a bacterial DNA compaction protein, is a prime example of a protein that is functionally modulated in response to environmental cues. These cues are translated into adapted gene expression patterns. We delve into the mechanisms underlying DNA compaction and its adaptation to environmental stimuli and explore the complex and subtle modulation of these diverse, yet difficult-to-study, structures.
- All authors
- Valk, R.A. van der
- Supervisor
- Ubbink, M.
- Co-supervisor
- Dame, R.T.
- Committee
- Brouwer, J.; Noteborn, M.H.M.; Grainger, D.; Wyman, C.; Goosen, N.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Leiden institute of Chemistry (LIC) , Science , Leiden University
- Date
- 2016-11-22
- ISBN
- 9789462955417
Funding
- Sponsorship
- This work was supported by a VIDI grant from The Netherlands Organization for Scientific Research (864.08.001) and NanoNextNL of the Government of the Netherlands and 130 partners.