Mechanical bowel preparation in elective open colon surgery

Leiden Repository

Mechanical bowel preparation in elective open colon surgery

Type: Doctoral Thesis
Title: Mechanical bowel preparation in elective open colon surgery
Author: Fa-Si-Oen, Patrick Regnier
Publisher: Department of Surgery, Faculty of Medicine, Leiden University
Issue Date: 2006-05-24
Keywords: Colon Surgery
Polyethylene Glycol
Butyrate
Wound Infection
Bacteriology
Anastomotic leak
Randomized trial
Mechanical bowel preparation
Abstract: Mechanical bowel preparation is a long standing practice in elective open colon surgery dating from the 1970's. It has always been believed to reduce the rate of postoperative complications in the form of anastomotic leakage and wound infection. In this thesis we broadly and thoroughly examine the various aspects and the value of mechanical bowel preparation in elective open colon surgery. - Mechanical bowel preparation in elective open colon surgery does not reduce the rate of anastomotic leak or wound infection nor does it reduce peritoneal bacterial contamination. It is however poorly tolerated by patients and the total workload for the nursing staff and health care costs are considerable. Therefore, it is superfluous in elective open colon surgery and should be abandoned. - The intraoperative subcutaneous bacterial swab is a powerful negative predictor of a postoperative wound infection in elective open colon surgery. -Mechanical bowel preparation with polythylene glycol causes no significant additional histopathologic damage of colonic tissue, in comparison with patients receiving a normal meal the night before open colon surgery. - Mechanical bowel preparation with polyethylene glycol does not significantly interfere with colon anastomotic healing in rats. - There is no significant benefit of a single dose of intraluminal 3.0 mMn-butyrate on colon anastomotic healing in rats after polyethylene glycol bowel preparation.
Description: Promotor: C.J.H. van de Velde, Co-Promotor: R.M.H. Roumen With Summaries in Dutch and Papiamento
Faculty: LUMC
Citation: Fa-Si-Oen, P.R., 2006, Doctoral Thesis, Leiden University
ISBN: 9090206981
9789090206981
Sponsor: de Nederlands Antilliaanse Stichting voor Klinisch Hoger Onderwijs Astra Zeneca and Martijn Trading division Curacao.
Handle: http://hdl.handle.net/1887/4427
 

Files in this item

Description Size View
application/pdf Propositions 103.4Kb View/Open
application/pdf Full text 2.355Mb View/Open
application/pdf Links to published articles 22.33Kb View/Open
application/msword Links to published articles 29.69Kb View/Open

This item appears in the following Collection(s)