Human longevity : crosstalk between the brain and periphery

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Human longevity : crosstalk between the brain and periphery

Type: Doctoral Thesis
Title: Human longevity : crosstalk between the brain and periphery
Author: Akintola, A.A.
Issue Date: 2016-11-16
Keywords: Ageing
Neuro-endocrine
Glucose
Insulin
Thyroid-axis
Heart rate
HRV
MRI
Intranasal-insulin
Abstract: Although mortality in old age has significantly decreased over the last fifty years in the developed world, there still remains a large inter-individual variability in ageing trajectories, morbidity and mortality. In the three parts of this thesis, we examined three interacting systems that have been identified as contributing to a slower pace of ageing, namely glucose/insulin metabolism (part I), the thyroid axis (part II), and the autonomic nervous system (part III). We found that familial longevity is associated with a stronger association of insulin parameters with microstructural brain parameters, and by higher TSH secretion, in the absence of differences in basal energy metabolism or differences in heart rate and its variability. Using specialized MRI techniques, we showed that subtle changes in microstructural brain parenchymal homogeneity in relation to insulin can be detected, even in brain tissue that appears normal on conventional MR imaging sequences. Insulin (rather than glucose), seemed to be a stronger indicator of micro- structural brain integrity in normo-glycemic older adults. Furthermore, intranasal application of insulin improved brain perfusion in parietal and occipital gray matter and in the thalamus of older adults. These results deepen our understanding of the physiological mechanisms and processes that underlie the ageing process.
Promotor: Supervisor: R. G. J. Westendorp Co-Supervisors: Diana van Heemst; Jeroen van der Grond
Faculty: Medicine
University: Leiden
Uri: urn:isbn:9789462334335
Handle: http://hdl.handle.net/1887/44266
 

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application/pdf Title page_Contents_List of abbreviations 1.587Mb View/Open
application/pdf Chapter 1 Gener ... ion aim and aims of thesis 1.470Mb View/Open
application/pdf Part I 1.443Mb View/Open
application/pdf Chapter 2 2.582Mb View/Open Full text at publisher site
application/pdf Chapter 3 3.010Mb View/Open Full text at publisher site
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application/pdf Part II 1.443Mb View/Open
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application/pdf Chapter 12 2.364Mb View/Open
application/pdf Appendices Summ ... edgements_Curriculum Vitae 689.3Kb View/Open
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