Persistent URL of this record https://hdl.handle.net/1887/44112
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- Oncoimmunology_3oe2014oee947892
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Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule
Aiming to increase the potency of synthetic long peptide (SLP)-based cancer vaccines, the Toll-like receptor 2 (TLR2) ligand Pam3CSK4 was conjugated in a chemically defined fashion to SLPs harbouring both cytotoxic T lymphocyte (CTL) and T helper epitopes. We recently showed that these SLP-conjugates induce strong antitumor immunity in murine cancer models.
- All authors
- Zom, G.G.; Filippov, D.V.; Marel, G.A. van der; Overkleeft, H.S.; Melief, C.J.; Ossendorp, F.A.
- Date
- 2014-08-03
- Journal
- OncoImmunology
- Volume
- 3
- Issue
- 7
- Pages
- e947892