Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

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Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

Type: Article / Letter to editor
Title: Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models
Author: Kramer, G.Wegdam, W.Donker-Koopman, W.Ottenhoff, R.Gaspar, P.Verhoek, M.Nelson, J.Gabriel, T.Kallemeijn, W.W.Boot, R.G.Laman, J.D.Vissers, J.P.Cox, T.Pavlova, E.Moran, M.T.Aerts, J.M.F.G.Eijk, M.C. van
Journal Title: FEBS Open Bio
Issue: 9
Volume: 6
Start Page: 902
End Page: 913
Pages: 12
Publisher: Wiley Open Access
Issue Date: 2016
Abstract: Gaucher disease is caused by inherited deficiency of lysosomal glucocerebrosidase. Proteome analysis of laser-dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB). Plasma gpNMB was also elevated, correlating with chitotriosidase and CCL18, which are established markers for human Gaucher cells. In Gaucher mice, gpNMB is also produced by Gaucher cells. Correction of glucocerebrosidase deficiency in mice by gene transfer or pharmacological substrate reduction reverses gpNMB abnormalities. In conclusion, gpNMB acts as a marker for glucosylceramide-laden macrophages in man and mouse and gpNMB should be considered as candidate biomarker for Gaucher disease in treatment monitoring.
Handle: http://hdl.handle.net/1887/44083
 

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