Basepair level modeling of the nucleosome and higher order structure

Leiden Repository

Basepair level modeling of the nucleosome and higher order structure

Type: Master thesis
Title: Basepair level modeling of the nucleosome and higher order structure
Author: Visscher, Lubertus Klaas
Issue Date: 2016-10-07
Keywords: DNA
Chromatin
Monte Carlo
Abstract: The aim of this study was to computationally resolve nucleosome dynamics and chromatin structure. To achieve this we ran Monte Carlo simulations of a base pair level model of a mononucleosome. Additionally, we developed a graphical user interface for generating a chromatin structure with realistic linker DNA, which enabled us to calculate linking number and writhe for different chromatin structures. The force extension curve of our simulated mononucleosome shows similar behaviour to force spectroscopy experiments.
Supervisor: Noort, John
Faculty: Faculty of Science
Department: Physics (Master)
Specialisation: Physics (experimental
ECTS Credits: 3
Handle: http://hdl.handle.net/1887/43978
 

Files in this item

Description Size View
application/pdf base-pair-level (1).pdf 3.445Mb View/Open

This item appears in the following Collection(s)