Dynamics of a GPCR studied with single-molecule microscopy

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Dynamics of a GPCR studied with single-molecule microscopy

Type: Doctoral Thesis
Title: Dynamics of a GPCR studied with single-molecule microscopy
Author: KeijzerSandra, de
Issue Date: 2006-04-12
Keywords: Single-molecule microscopy
Chemotaxis
Fluorescent proteins
G-protein coupled receptor
Dictyostelium discoideum
Mobility
Abstract: The behavior of single G-protein coupled receptor molecules were studied with single-molecule microscopy in the plasmamembrane during Dictyostelium discoideum chemotaxis. The mobility of the receptor was different in the anterior and posterior regions of living cells migrating towards the source of chemoattractant. This difference of mobility can account for an amplification of the extracellular signal, necessary for chemotaxis. It was also found that the receptor molecules are internalized.
Promotor: Supervisor: T. Schmidt|H.P. Spaink Co-Supervisor: B.E. Snaar-Jagalska
Faculty: Faculty of Science
University: Leiden University
Handle: http://hdl.handle.net/1887/4363
 

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