Dynamics of a GPCR studied with single-molecule microscopy

Leiden Repository

Dynamics of a GPCR studied with single-molecule microscopy

Type: Doctoral Thesis
Title: Dynamics of a GPCR studied with single-molecule microscopy
Author: KeijzerSandra, de
Issue Date: 2006-04-12
Keywords: Single-molecule microscopy
Fluorescent proteins
G-protein coupled receptor
Dictyostelium discoideum
Abstract: The behavior of single G-protein coupled receptor molecules were studied with single-molecule microscopy in the plasmamembrane during Dictyostelium discoideum chemotaxis. The mobility of the receptor was different in the anterior and posterior regions of living cells migrating towards the source of chemoattractant. This difference of mobility can account for an amplification of the extracellular signal, necessary for chemotaxis. It was also found that the receptor molecules are internalized.
Promotor: Supervisor: T. Schmidt|H.P. Spaink Co-Supervisor: B.E. Snaar-Jagalska
Faculty: Faculty of Science
University: Leiden University
Handle: http://hdl.handle.net/1887/4363

Files in this item

Description Size View
application/pdf chapter5.pdf 91.44Kb View/Open
application/pdf stellingen.pdf 53.16Kb View/Open
application/pdf CV+and+publications.pdf 39.62Kb View/Open
application/pdf chapter4.pdf 1.480Mb View/Open
application/pdf Chapter 3 2.386Mb View/Open
application/pdf Chapter 2 1.729Mb View/Open
application/pdf Chapter 1 5.274Mb View/Open
application/pdf Title Page 34.53Kb View/Open
application/pdf Cover+Final_1_.ps.pdf 1.200Mb View/Open

This item appears in the following Collection(s)