Neuroendocrine perturbations in human obesity

Leiden Repository

Neuroendocrine perturbations in human obesity

Type: Doctoral Thesis
Title: Neuroendocrine perturbations in human obesity
Author: Kok, Petra
Publisher: Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2006-04-03
Keywords: Obesity
Growth hormone
HPA axis
Visceral fat mass
Weight loss
Dopamine 2 Receptor
Free Fatty Acids
Abstract: The evolutionary advantage to conserve energy in the form of adipose issue in order to survive long periods of food shortage in the past, turned into a major health problem in current times of plenty. Excess accumulation of body fat, or “obesity”, is associated with severely increased co-morbidity and mortality risks and is a global epidemical medical condition which is difficult to manage. The exact pathophysiologic mechanism of obesity remains elusive and various factors such as genetic, social, behavioral and physiological cues are involved in its development. From a biological point of view, obesity might be partly explained by differences in the regulation of energy intake, expenditure and storage (energy homeostasis) between obese and lean individuals. The neuroendocrine system provides a source of humoral messengers, which modulate energy homeostasis. This thesis will focus on changes of the neuroendocrine environment of obese women. First of all, spontaneous diurnal plasma hormone concentrations and secretion of different hormonal systems were studied. Secondly, the effect of weight loss on neuroendocrine perturbations of some of these hormonal axes was evaluated. Finally, the impact of modulation of potential physiological cues (increased circulating FFAs and deficit dopaminergic signaling), which might be involved in the neuroendocrine changes and metabolic alterations, was investigated.
Description: Promotor: A.E. Meinders, Co-promotores: H. Pijl en F. Roelfsema, Referent: A.R.M.M. Hermus
With summary in Dutch
Faculty: LUMC
Citation: Kok, P., 2006, Doctoral thesis, Leiden University
ISBN: 9789090205342

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