Blood pressure, cardiac biomarkers and cognitive function in old age

Leiden Repository

Blood pressure, cardiac biomarkers and cognitive function in old age

Type: Doctoral Thesis
Title: Blood pressure, cardiac biomarkers and cognitive function in old age
Author: Wijsman, L.W.
Issue Date: 2016-10-11
Keywords: Cognition
Cardiac function
Blood pressure
Ageing
Abstract: With the increase in life expectancy, the prevalence of cognitive disorders is expected to rise the coming years. In this thesis we studied the association between blood pressure, cardiac biomarkers and cognitive function in 5800 people with mean age of 75 years. Furthermore, we investigated the feasibility to use smartphone technology to measure home blood pressure in 151 people during a 6 months follow-up period. We show that higher variability in blood pressure is associated with increased microdamage of the brain and worse cognitive function, independent of average blood pressure and use of blood pressure lowering medication. Furthermore, increased levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT), both markers of cardiac disease, are associated with worse cognitive function and steeper cognitive decline, independent of cardiovascular diseases or risks. Finally, we show that smartphone-based technology is a reliable and promising method with good adherence to measure blood pressure at home. This provides a possibility for implementation in large-scale studies and can potentially contribute to blood pressure reduction, eventually helping to prevent cognitive impairment.
Promotor: Supervisor: R.G.J. Westendorp Co-Supervisor: S.P. Mooijaart
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789462333512
Handle: http://hdl.handle.net/1887/43494
 

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application/pdf Title Pages_Contents 93.82Kb View/Open
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application/pdf Part I: Chapter 2 3.723Mb Under embargo until 2018-04-11
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application/pdf Publications_Curriculum Vitae_Acknowledgements 128.7Kb View/Open
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