Diagnostics and treatment options in low-grade central chondrosarcomas

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Diagnostics and treatment options in low-grade central chondrosarcomas

Type: Doctoral Thesis
Title: Diagnostics and treatment options in low-grade central chondrosarcomas
Author: Verdegaal, S.H.M.
Issue Date: 2016-10-12
Keywords: Low-grade chondrosarcoma
Phenol curettage
ACT
Morbus Ollier
Maffucci syndrome
Abstract: The first part of my thesis concerns a multicenter study in nine different European countries of patients with one of the rare diseases Ollier disease or Maffucci syndrome. We collected clinical data to look to factors that predict prognosis and chance to develop secondary chondrosarcoma. In the second part of this thesis describes different aspects in the intralesional treatment of low-grade chondrosarcoma of long bones. In our series, we used phenol as an adjuvant therapy. First, the cell-killing effect of phenol was investigated. Also, clinical parts of the surgery were studied. We described a patients series of patients treated this way. Also, we looked to the postoperative characteristics on Gd-MRI.
Promotor: Supervisors: A.H.M. Taminiau; P.C.W. Hogendoorn
Faculty: Medicine
University: Leiden
Uri: urn:isbn:9789402801774
Handle: http://hdl.handle.net/1887/43475
 

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application/pdf Chapter 1 General introduction 124.8Kb View/Open
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application/pdf Chapter 7 Summa ... ion and concluding remarks 118.3Kb View/Open
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application/pdf Chapter 9 List of publications 138.7Kb View/Open
application/pdf Chapter 10 Curriculum Vitae 187.4Kb View/Open
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