The skin as a mirror of the aging process

Leiden Repository

The skin as a mirror of the aging process

Type: Doctoral Thesis
Title: The skin as a mirror of the aging process
Author: Waaijer, M.E.C.
Issue Date: 2016-10-12
Keywords: Cellular senescence
Aging
Skin
Fibroblasts
p16INK4a
Familial longevity
Perceived age
Abstract: This thesis describes to which extent the skin reflects the aging process, with a specific focus on cellular senescence. Since the first descriptions of the growth arrested state of fibroblasts upon multiple replication rounds, cellular senescence has now emerged as a promising target to regulate the aging process in vivo as well. Here, we study whether fibroblast senescence in vitro is associated with in vivo donor characteristics such as chronological age and prevalence of disease. We further describe in this thesis whether senescence in skin tissue (in situ) is associated with other histological skin characteristics and with in vivo donor characteristics.
Promotor: Supervisors: R.G.J. Westendorp; A.B. Maier
Faculty: Medicine
University: Leiden
Uri: urn:isbn:9789462333826
Handle: http://hdl.handle.net/1887/43472
 

Files in this item

Description Size View
application/pdf Cover 788.6Kb View/Open
application/pdf Full text 37.41Mb View/Open
application/pdf Title page_Contents 1.873Mb View/Open
application/pdf General introduction and outline of the thesis 1.894Mb View/Open
application/pdf Part I 4.291Mb View/Open
application/pdf Chapter 1 3.172Mb View/Open Full text at publisher site
application/pdf Chapter 2 3.783Mb View/Open Full text at publisher site
application/pdf Chapter 3 2.228Mb View/Open
application/pdf Part II 3.679Mb View/Open
application/pdf Chapter 4 3.227Mb View/Open Full text at publisher site
application/pdf Chapter 5 4.725Mb View/Open Full text at publisher site
application/pdf Chapter 6 3.988Mb View/Open Full text at publisher site
application/pdf Part III 3.679Mb View/Open
application/pdf Chapter 7 3.208Mb View/Open
application/pdf Chapter 8 4.067Mb View/Open Full text at publisher site
application/pdf Summary and dis ... edgements_Curriculum Vitae 1.932Mb View/Open
application/pdf Propositions 70.36Kb View/Open

This item appears in the following Collection(s)