Molecular and cellular determinants of cardiac tachyarrhythmias: from trigger to therapy

Leiden Repository

Molecular and cellular determinants of cardiac tachyarrhythmias: from trigger to therapy

Type: Doctoral Thesis
Title: Molecular and cellular determinants of cardiac tachyarrhythmias: from trigger to therapy
Author: Bingen, B.O.
Issue Date: 2016-10-05
Keywords: Arrhythmia
Atrial fibrillation
Ventricular fibrillation
Defibrillation
Optogenetics
Abstract: Cardiac tachyarrhythmias are a vast contributor to morbidity and mortality worldwide. Still, the mechanisms underlying these arrhythmias are incompletely understood. As a result, many of the treatment options available for these arrhythmias rely on sole alleviation of symptoms or prevention of complications secondary to the arrhythmia, or are associated with non-trivial adverse effects. An increased understanding of the mechanisms underlying cardiac tachyarrhythmias as well as the means to reverse them is a critical prerequisite if we are to shift towards more specific, more effective and less harmful arrhythmia treatment. Therefore, the research described in this thesis investigates the molecular and cellular determinants of cardiac tachyarrhythmias in ex vivo and in vitro models of cardiac hypertropfy/fibrosis, ventricular fibrillation and atrial fibrillation using state of the art electrophysiological and genetic tools.
Promotor: Supervisor: M.J. Schalij Co-Supervisors: D.A. Pijnappels; A.A.F. de Vries
Faculty: Medicine
University: Leiden
Uri: urn:isbn:9789462333543
Handle: http://hdl.handle.net/1887/43389
 

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