The responses of cardiac cells to stress : focus on irradiation and mechanical stretch

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The responses of cardiac cells to stress : focus on irradiation and mechanical stretch

Type: Doctoral Thesis
Title: The responses of cardiac cells to stress : focus on irradiation and mechanical stretch
Author: Wees, Caroline Geertruida Christina van der
Publisher: Dept. of Cardiology, Faculty of Medicine (LUMC), Leiden University
Issue Date: 2006-01-24
Keywords: Hypertrophy
Mechanical stress
Nucleotide excision repair
Apoptosis
Integrins
Neonatal rat heart cells
Calcium signaling
Micro-array
Abstract: The heart is built for life-long uninterrupted function, supporting blood flow through the organism. During life, the organism as well as its organs will become challenged by exogenous and endogenous stresses that should be coped with. To be able to adapt to stresses such as altered loading conditions, changes in myocardial perfusion and exposure to toxic agents, the heart possesses ample capabilities. This thesis deals with the question how cardiac cells react to different stresses in an attempt to adapt to the new circumstances. The effect of mechanical stress as well as integrin stimulation on cardiac cells was examined and described. Besides we investigated the reaction of cardiac cells to DNA damage caused by either ionizing radiation or UV-irradiation. The studies reported in this thesis confirm that cardiac cells, both myocytes and fibroblasts have the capacity to respond adequately to exogenous stresses. The responses that have been studied in detail demonstrate that these cells possess systems that sense the stress, transmit its message to the cell interior, and alter gene expression, leading to appropriate reactions.
Description: Promotores: A. van der Laarse, A.A. van Zeeland.
With summary in Dutch
Faculty: LUMC
Citation: Wees, C.G.C. van der, 2006, Doctoral Thesis, Leiden University
Sponsor: Financial Support by the Netherlands Heart Foundation
Handle: http://hdl.handle.net/1887/4268
 

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