Adverse environmental conditions influence age-related innate immune repsonsiveness

Leiden Repository

Adverse environmental conditions influence age-related innate immune repsonsiveness

Type: Article / Letter to editor
Title: Adverse environmental conditions influence age-related innate immune repsonsiveness
Author: May, Linda; Biggelaar, Anita HJ van den; Bodegom, David van; Meij, Hans J; Craen, Anton JM de; Amankwa, Joseph; Frölich, Marijke; Kuningas, Maris and Westendorp, Rudi GJ
Publisher: BioMed Central
Issue Date: 2009
Abstract: Background-: The innate immune system plays an important role in the recognition and induction of protective responses against infectious pathogens, whilst there is increasing evidence for a role in mediating chronic inflammatory diseases at older age. Despite indications that environmental conditions can influence the senescence process of the adaptive immune system, it is not known whether the same holds true for the innate immune system. Therefore we studied whether agerelated innate immune responses are similar or differ between populations living under very diverse environmental conditions. Methods-: We compared cross-sectional age-related changes in ex vivo innate cytokine responses in a population living under affluent conditions in the Netherlands (age 20–68 years old, n = 304) and a population living under adverse environmental conditions in Ghana (age 23–95 years old, n = 562). Results-: We found a significant decrease in LPS-induced Interleukin (IL)-10 and Tumor Necrosis Factor (TNF) production with age in the Dutch population. In Ghana a similar age-related decline in IL-10 responses to LPS, as well as to zymosan, or LPS plus zymosan, was observed. TNF production, however, did not show an age-associated decline, but increased significantly with age in response to co-stimulation with LPS and zymosan. Conclusion-: We conclude that the decline in innate cytokine responses is an intrinsic ageing phenomenon, while pathogen exposure and/or selective survival drive pro-inflammatory responses under adverse living conditions.
Citation: Immunity & Ageing 2009, 6 :7

Files in this item

Description Size View
application/pdf Immunity & Ageing 2009, 6:7 377.7Kb View/Open Full text at publisher site

This item appears in the following Collection(s)