Clinical allergy : basophils, T cells, and therapeutic design

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Clinical allergy : basophils, T cells, and therapeutic design

Type: Doctoral Thesis
Title: Clinical allergy : basophils, T cells, and therapeutic design
Author: Voskamp, A.L.
Issue Date: 2016-06-16
Keywords: Peanut allergy
Peptide immunotherapy
Antigen presentation
Basophil activation test
Abstract: The first aim of this thesis was to investigate basic components of the initiation of an allergic response, including the route of sensitization and the cells responsible for the initiation of Th2 skewing in allergic subjects. More specifically, both clinical and immunological evidence of food allergy development through cutaneous sensitization were presented in the form of a case study. Furthermore the ability of human basophils to initiate a Th2 response through direct antigen presentation to T cells was investigated. The second aim of this thesis is to investigate the use of current therapies and the development of new therapies for difficult-to-treat allergic diseases. Dominant T-cell epitopes of major peanut allergen proteins were identified and characterized providing the first step in the design of a safe and effective peptide based T cell targeted immunotherapy to treat peanut allergy. Finally, the immunological and clinical efficacy of omalizumab for the treatment of allergic bronchopulmonary aspergillosis was assessed, for the first time, in a randomized placebo-controlled clinical trial. Throughout these studies, basophils played an important role as either the object of investigation or as a tool in diagnosis, allowing determination of the efficacy of existing therapeutics, or assessment of the safety of novel therapies.
Promotor: Supervisors: M. Yazdanbakhsh; R.E. O’Hehir Co-Supervisor: S.R. Prickett
Faculty: Medicine
University: Leiden
Uri: urn:isbn:9789491602634
Handle: http://hdl.handle.net/1887/41190
 

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application/pdf Appendix Summar ... Vitae_List of publications 130.9Kb View/Open
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