Two Dimensional Diffusion of Colloidal Particles on Supported Lipid Bilayers

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Two Dimensional Diffusion of Colloidal Particles on Supported Lipid Bilayers

Type: Master thesis
Title: Two Dimensional Diffusion of Colloidal Particles on Supported Lipid Bilayers
Author: Vegter, Ernst Jan
Issue Date: 2015-10-16
Keywords: Diffusion
Colloids
Lipid Bilayer
Curved surfaces
Abstract: We seek to study the in uence of substrate geometry on di usion of substrate attached particles by building a model system in which colloidal particles are attached to a supported lipid bilayer on TPA suitable material. We test a variety of lipid compositions and polyelectrolyte cushioning with respect to lipid mobility. Our experimental e orts show that DOPC/DOPE-PEG2000 uid lipid bilayers on glass and ORMOCER can be created. DNA linkers with cholesterol anchors are adsorbed in this bilayer and polystyrene colloids coated with complementary DNA linkers are coupled to the linkers in the bilayer. We show that the colloids di use in a two dimensional fashion on a glass substrate.
Supervisor: Kraft, Daniela
Faculty: Faculty of Science
Department: Physics (Master)
Specialisation: Experimental Physics
ECTS Credits: 5
Handle: http://hdl.handle.net/1887/40571
 

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