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Analysis of the neo-antigen specific T cell response : and consequences for personalized immunotherapy
Cancer immunotherapy has shown clinical effectiveness over the recent years, especially in patients with a high mutational load in the tumor.
Mutated epitopes, so called 'neo-antigens', are presented on the tumor and can be regarded as foreign by the immune system.
In this thesis, the importance of neo-antigens in the anti-tumor response is explored.
First, the characteristics of antigens that can be recognized on human tumors are described, with a specific focus on neo-antigens.
Second, technologies are described to systematically analyze neo-antigen specific reactivity in patients with cancer.
Third, I show that neo-antigen specific reactivity is a common phenomenon in the CD4 and CD8 T cell compartments of patients with melanoma.
Finally, I discuss what the expected value of neo-antigens is in the context of personalized cancer-immunotherapy.
- All authors
- Buuren, M.M. van
- Supervisor
- Schumacher, Ton N.M.
- Co-supervisor
- Kesmir, Can
- Committee
- Haanen, John B.A.G.; Melief, Kees C.J.M.; Heemskerk, Mirjam H.M.; Ossendorp, Ferry A.; Kuball, Jurgen; Sahin, Ugur
- Qualification
- Doctor (dr.)
- Awarding Institution
- Leiden University Medical Center , Medicine , Leiden University
- Date
- 2016-06-01
- ISBN
- 9789462332973
Funding
- Sponsorship
- NKI-AvL