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PD-1 Expression in primary cutaneous lymphoma
The molecule programmed death-1 (PD-1) is a critical element in the negative regulation of cellular immune responses. Blockage of the interaction between PD-1 and its ligand PD-L1 has emerged as a promising therapeutic approach for several cancers underlining the importance of this molecule. Expression of PD-1 has been used as valuable marker in the differentiation between different types of T-cell non-Hodgkin lymphoma. The studies presented in this thesis are focused on the expression of PD-1 in primary cutaneous T-cell lymphomas and cutaneous B-cell lymphomas in order to determine whether expression of PD-1 might also be a useful marker in the diagnosis of different types of cutaneous lymphoma. Differentiation between the different types of cutaneous lymphoma is extremely important, as they have a completely different prognosis and require different types of treatment. The investigations in this thesis provide a detailed...
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The molecule programmed death-1 (PD-1) is a critical element in the negative regulation of cellular immune responses. Blockage of the interaction between PD-1 and its ligand PD-L1 has emerged as a promising therapeutic approach for several cancers underlining the importance of this molecule. Expression of PD-1 has been used as valuable marker in the differentiation between different types of T-cell non-Hodgkin lymphoma. The studies presented in this thesis are focused on the expression of PD-1 in primary cutaneous T-cell lymphomas and cutaneous B-cell lymphomas in order to determine whether expression of PD-1 might also be a useful marker in the diagnosis of different types of cutaneous lymphoma. Differentiation between the different types of cutaneous lymphoma is extremely important, as they have a completely different prognosis and require different types of treatment. The investigations in this thesis provide a detailed description of the differential expression of PD-1 in distinct types of cutaneous lymphomas, revealing that PD-1 has the potential of a diagnostic biomarker, especially for Sézary syndrome and primary cutaneous small/medium-sized pleomorphic T cell lymphoma. The overall conclusion is that PD-1 may serve as a suitable adjunct to improve diagnosis, and may enable better classification of provisionally classified cutaneous lymphoma entities.
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- All authors
- Cetinozman, F.
- Supervisor
- Willemze, R.
- Co-supervisor
- Jansen, P.M.
- Committee
- Dijk, M.R. van; Krieken, J.H.J.M van; Smit, V.T.H.B.M.; Vermeer, M.H.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Department of Dermatology , Leiden University Medical Center (LUMC) , Leiden University
- Date
- 2016-04-20
- ISBN
- 9789461826756