The Milan Geriatrics 75+ Cohort Study: unravelling the determinants of healthy ageing and longevity

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The Milan Geriatrics 75+ Cohort Study: unravelling the determinants of healthy ageing and longevity

Type: Doctoral Thesis
Title: The Milan Geriatrics 75+ Cohort Study: unravelling the determinants of healthy ageing and longevity
Author: OgliariGiulia
Issue Date: 2016-04-05
Keywords: Mortality
Functional status
Cognition
Thyroid
Heart rate
Blood pressure
Ageing
Abstract: Current evidence on older adults is derived from population-based cohort studies and randomized controlled trials, which may not include frail individuals. Data are lacking on older outpatients, a potentially diverse population. Therefore, we initiated the Milan Geriatrics 75+ Cohort Study, a prospective hospital-based outpatient cohort study. Chapter 1 of this thesis provides a background on the controversies regarding the homeostasis of older adults. Chapter 2, 3 and 4 report findings from the Milan Geriatrics 75+ Cohort Study. Chapter 2 explores the association between blood pressure and cognition, and whether it varies according to age and functional status. Chapter 3 examines the relationship between blood pressure and mortality risk, and whether it varies according to functional and cognitive status. Chapter 4 investigates the association between thyroid status and mortality risk in euthyroid older adults, and whether it differs by sex and age. Chapter 5 and 6 report findings from the PROSPER cohort, which includes older adults at high cardiovascular risk. Chapter 5 presents new evidence on the association of heart rate and heart rate variability with functional decline. Chapter 6 analyses the relationship between blood pressure variability and functional decline. Chapter 7 summarises and discusses the main findings of this thesis.
Promotor: Supervisor: R.G.J. Westendorp Co-Supervisor: A.J.M. de Craen|D. Mari
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden University
Uri: urn:isbn:9789064649899
Handle: http://hdl.handle.net/1887/38711
 

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application/pdf Title Pages_Contents 230.5Kb View/Open
application/pdf Chapter 1 356.8Kb View/Open
application/pdf Chapter 2 728.1Kb View/Open Full text at publisher site
application/pdf Chapter 3 689.2Kb View/Open Full text at publisher site
application/pdf Chapter 4 827.1Kb View/Open
application/pdf Chapter 5 619.3Kb View/Open Full text at publisher site
application/pdf Chapter 6 646.8Kb View/Open
application/pdf Chapter 7 353.6Kb View/Open
application/pdf Chapter 8: Summary in English 228.5Kb View/Open
application/pdf Chapter 9: Summary in Italian 212.7Kb View/Open
application/pdf Chapter 10: Summary in Dutch 230.0Kb View/Open
application/pdf Publications_Curriculum Vitae_Acknowledgements 258.2Kb View/Open
application/pdf Propositions 110.9Kb View/Open

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