Roles of mDia formins in actin-dependent and –independent processes

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Roles of mDia formins in actin-dependent and –independent processes

Type: Doctoral Thesis
Title: Roles of mDia formins in actin-dependent and –independent processes
Author: Isogai, Tadamoto
Publisher: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2016-02-25
Keywords: Formins
Actin
DRFs
mDia1
mDia2
p53
Lamellipodia
Gene transcription
Proteasome
Abstract: In this thesis, we studied the Diaphanous-Related Formins (DRFs) mDia1 and mDia2 for their actin-dependent and -independent roles in several cellular processes, including lamellipodia/ruffle formation and cell migration, gene transcription, and proteasome-dependent protein homeostasis. In addition we systematically characterized a widely employed general Formin inhibitor SMFIH2. This thesis highlights actin-dependent and -independent functions of the DRFs mDia1 and mDia2, and sheds new light on novel mode of action for DRFs.
Description: Promotor: J.J. Neefjes, Co-promoter: M. Innocenti
With summary in Dutch
Faculty: LUMC
Citation: Isogai, T., 2016, Doctoral Thesis, Leiden University
ISBN: 9789461826428
Handle: http://hdl.handle.net/1887/38042
 

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