Pituitary hormone secretion in familial longevity : The Switchbox Study

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Pituitary hormone secretion in familial longevity : The Switchbox Study

Type: Doctoral Thesis
Title: Pituitary hormone secretion in familial longevity : The Switchbox Study
Author: Jansen, Wilhelmina Maria
Publisher: Department of Gerontology and Geriatrics, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2016-02-03
Keywords: Healthy ageing
Homeostasis
HPT-axis
HPA-axis
Familial longevity
Deconvolution
Rhythms
Stress
Abstract: The overall hypothesis of the Switchbox study is that maintenance of homeostasis is pivotal for maintenance of health in old age. Therefore, the aim of this thesis as part of the Switchbox study, was to expand our knowledge of homeostatic mechanisms at old age, thus trying to unravel underlying mechanisms of healthy human longevity. The focus of this thesis will be on analysis of the HPT-axis and HPA-axis in participants who have the propensity to reach old age in good health compared to age-matched controls. In humans, we are able to assess the ‘function’ of the HPT- and HPA- axes by measuring the key hormones involved as well as physiological parameters that are affected by these systems (heart rate, metabolism) under different conditions (in rest and during stress).
Description: Promotoren: R.G.J. Westendorp, H. Pijl, Co-promotor: D. van Heemst
With summary in Dutch
Faculty: LUMC
Citation: Jansen, W.M., 2016, Doctoral Thesis, Leiden University
ISBN: 9789402800203
Sponsor: The work described in this thesis was supported by the European Commission project Switchbox (FP7, Health-F2-2010-259772).
Handle: http://hdl.handle.net/1887/37577
 

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application/pdf Chapter 1 Gener ... and outline of the thesis 517.8Kb View/Open
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application/pdf Chapter 9 General discussion 504.6Kb View/Open
application/pdf Summary in Dutch 167.2Kb View/Open
application/pdf List of publica ... lum Vitae_Acknowledgements 97.40Kb View/Open
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