The role of geriatric assessment prior to chemotherapy in elderly patients with cancer

Leiden Repository

The role of geriatric assessment prior to chemotherapy in elderly patients with cancer

Type: Doctoral Thesis
Title: The role of geriatric assessment prior to chemotherapy in elderly patients with cancer
Author: Aaldriks, Aaldrik Albertus
Publisher: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2015-11-17
Keywords: Geriatric assessment
Elderly
Prognostic factors
Chemotherapy
Abstract: The decision to treat elderly patients with cancer aged 70 years or older with chemotherapy is generally based on clinical judgment of the clinician, in combination with the evidence obtained from clinical studies performed in younger age groups. The instrument GA might be helpful to detect hidden shortcomings and may aid clinical decision making with regard to the feasibility of treatment with chemotherapy and prediction of survival in the elderly patients with cancer. The following questionnaires and tests were considered appropriate to obtain a practical GA: MNA, GFI, IQCODE, MMSE, and laboratory values of albumin, creatinine, lactate dehydrogenase and hemoglobin. The main questions we tried to answer were firstly to assess the predictive value prior to the start of chemotherapy of the chosen GA with respect to the probability to complete the planned chemotherapy and overall survival and secondly to analyze and determine which elements of the chosen GA were independently predictive to complete chemotherapy and which elements predicted early mortality.This thesis is the result of clinical research on certain elements of GA that might be useful for routine daily oncology practice, in order to select the proper patients and improve the outcome of treatment with chemotherapy.
Description: Promotor: J.W.R. Nortier, Co-promotores: E. Maartense, E.J. Giltay
With summary in Dutch
Faculty: LUMC
Citation: Aaldriks, A.A., 2015, Doctoral Thesis, Leiden University
ISBN: 9789090293394
Handle: http://hdl.handle.net/1887/36359
 

Files in this item

Description Size View
application/pdf Full text 3.384Mb View/Open
text/html Chapter 6 link to the published article 26.44Kb View/Open
application/pdf Cover 663.0Kb View/Open
application/pdf Title page_Table of contents 215.1Kb View/Open
application/pdf Chapter 1 Introduction 1.008Mb View/Open
application/pdf Chapter 2 1.102Mb View/Open Full text at publisher site
application/pdf Chapter 3 1.210Mb View/Open Full text at publisher site
application/pdf Chapter 4 1.062Mb View/Open Full text at publisher site
application/pdf Chapter 5 1.241Mb View/Open Full text at publisher site
application/pdf Chapter 6 685.6Kb View/Open Full text at publisher site
application/pdf Chapter 7 Summa ... eneral discussion in Dutch 1.184Mb View/Open
application/pdf Appendices 398.1Kb View/Open
application/pdf Author affiliat ... edgements_Curriculum Vitae 265.6Kb View/Open
application/pdf Propositions 141.8Kb View/Open

This item appears in the following Collection(s)