Computational modeling of mycobacterium infection and innate immune reponse in zebrafish

Leiden Repository

Computational modeling of mycobacterium infection and innate immune reponse in zebrafish

Type: Doctoral Thesis
Title: Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Author: Viana de Carvalho, Rafael
Publisher: Leiden Institute of Advanced Computer Science (LIACS), Faculty of Science, Leiden University
Issue Date: 2015-10-15
Keywords: Computational Modeling
Petri nets
3D Simulation
Mycobacterium Infection
Abstract: In this thesis we provided a comprehensive overview on the steps that are involved in the modeling process and simulation of biological phenomena; from the choice of the method to the validation of the results. We gradually implemented a model with which we would be able to study the complex interplay of the components involved in the Mycobacterium marinum infection process and innate immune response in zebrafish embryos. In itself this process is a model for deeper understanding of tuberculosis infection in humans using zebrafish as model organism. Each chapter is a building block in the modeling process, which gradually forms a model that can represent cause-and-effect among these components involved in the biological behavior.
Description: Promotor: J.N. Kok, Co-Promotor: F.J. Verbeek
With Summary in Portuguese
With Summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Viana de Carvalho, R., 2015, Doctoral Thesis, Leiden University
ISBN: 9789462598812
Handle: http://hdl.handle.net/1887/35896
 

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application/pdf Title Pages_Contents_Preface 260.9Kb View/Open
application/pdf Chapter 1 561.7Kb View/Open
application/pdf Chapter 2 1.274Mb View/Open Full text at publisher site
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application/pdf Chapter 6 262.6Kb View/Open
application/pdf References_Appendices 337.0Kb View/Open
application/pdf Summary in English 212.8Kb View/Open
application/pdf Summary in Portuguese 212.3Kb View/Open
application/pdf Summary in Dutch 217.1Kb View/Open
application/pdf Publications_Curriculum Vitae 178.6Kb View/Open
application/pdf Propositions 120.6Kb View/Open

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