Statistical methods for genetic association studies with response-selective sampling designs

Leiden Repository

Statistical methods for genetic association studies with response-selective sampling designs

Type: Doctoral Thesis
Title: Statistical methods for genetic association studies with response-selective sampling designs
Author: Balliu, Brunilda
Publisher: Medical Statistics and Bioinformatics, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2015-09-10
Keywords: Ascertainment correction
Case-controls studies
Family-based studies
Maximum likelihood
Response-selective sampling
Abstract: This dissertation describes new statistical methods designed to improve the power of genetic association studies. Of particular interest are studies with a response-selective sampling design, i.e. case-control studies of unrelated individuals and case-control studies of family members. The statistical methods presented in this dissertation (a) take advantage of information available in the distribution of the covariates in case-control studies by modeling the ascertainment process; (b) incorporate information from both family-based studies and case-control studies of unrelated individuals; (c) use "richer" models of the relationship between genetic variants and phenotypes, compared to models used in standard genetic association studies; and (d) integrate different types of data, such as genomic, epigenomic, transcriptomic and environmental information. Together, these methods will improve the ability of the genetics community to identify the genetic basis of complex human phenotypes.
Description: Promotor: J.J. Houwing-Dustermaat, Co-Promotor: S. Boehringer
With summary in Dutch
Faculty: LUMC
Citation: Balliu, B., 2015, Doctoral Thesis, Leiden University
ISBN: 9789461825841
Sponsor: Research leading to this thesis was supported by the Netherlands Organization for Scientific Research Grant (917.66.344), the Dutch Arthritis Foundation (Reumafonds), European Union's Seventh Framework Program for research under grant agreement no. 305280(MIMOmics), and two grants from the German Research Foundation; BO 1955/2-3 and WU 314/6-2.
Handle: http://hdl.handle.net/1887/35195
 

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application/pdf Chapter 1 Intro ... enetic association studies 438.3Kb View/Open
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application/pdf Bibliography 202.3Kb View/Open
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application/pdf Summary in Dutch 171.3Kb View/Open
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