Refining EGFR-monoclonal antibody treatment in colorectal cancer

Leiden Repository

Refining EGFR-monoclonal antibody treatment in colorectal cancer

Type: Doctoral Thesis
Title: Refining EGFR-monoclonal antibody treatment in colorectal cancer
Author: Krens, Lisanne Laura
Publisher: Department of Clinical Pharmacy and Toxicology and Clinical Oncology, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2015-07-02
Keywords: EGFR-antibodies
Metastatic colorectal cancer
Cetuximab
Panitumumab
FCGR3A
KRAS
Organ dysfuction
Abstract: The use of the epidermal growth factor receptor (EGFR) antibodies cetuximab and panitumumab is limited to colorectal cancer (CRC) patients with KRAS wild type tumors and more recently in RAS wild type only. After having become chemotherapy refractory, treatment options are limited for this substantial patient group. This means that there is an urgent need to optimize anti-EGFR therapy. The work presented in this thesis aimed at optimising EGFR targeted monoclonal antibody therapy in metastatic CRC. This thesis investigates several strategies to refine EGFR targeted monoclonal antibody therapy in CRC by: 1. statins and their ability to phenoconvert KRAS mutant CRC; 
 2. exploration of polymorphisms in the gene encoding FCGR3A and their association 
with cetuximab efficacy; 
 3. and investigating the pharmacokinetics of cetuximab and panitumumab in patients with renal or hepatic dysfunction. 

Description: Promotores: H.-J. Guchelaar, A.J. Gelderblom, Co-promotor: R.J.H.M. van der Straaten
With summary in Dutch
Faculty: LUMC
Citation: Krens, L.L., 2015 Doctoral Thesis, Leiden University
ISBN: 97894920260507
Sponsor: Raad van bestuur ZGT AZL Onderzoeks- en ontwikkelingskrediet apotheek
Handle: http://hdl.handle.net/1887/33832
 

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application/pdf Full text 2.850Mb View/Open
application/pdf Cover 106.3Kb View/Open
application/pdf Title page_Table of contents 128.9Kb View/Open
application/pdf Chapter 1 General introduction 241.2Kb View/Open
application/pdf Part I 125.4Kb View/Open
application/pdf Chapter 2 389.6Kb View/Open Full text at publisher site
application/pdf Chapter 3 1.647Mb View/Open
application/pdf Chapter 4 417.2Kb View/Open Full text at publisher site
application/pdf Chapter 5 289.0Kb View/Open
application/pdf Chapter 6 255.0Kb View/Open
application/pdf Chapter 7 376.3Kb View/Open
application/pdf Part II 141.8Kb View/Open
application/pdf Chapter 8 227.4Kb View/Open Full text at publisher site
application/pdf Chapter 9 234.3Kb View/Open Full text at publisher site
application/pdf Chapter 10 General discussion 201.5Kb View/Open
application/pdf Chapter 11 Summary 170.2Kb View/Open
application/pdf Chapter 12 Summary in Dutch 173.4Kb View/Open
application/pdf Acknowledgement ... Vitae_List of publications 175.6Kb View/Open
application/pdf Propositions 93.74Kb View/Open

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