The affective amygdala : towards a better understanding of adolescent depressive and anxiety disorders

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The affective amygdala : towards a better understanding of adolescent depressive and anxiety disorders

Type: Doctoral Thesis
Title: The affective amygdala : towards a better understanding of adolescent depressive and anxiety disorders
Author: Bulk, Bianca Gabriella van den
Publisher: Department of Child and Youth Psychiatry, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2015-06-02
Keywords: Adolescence
Depression
Anxiety
Emotional face processing
Amygdala
Longitudinal
fMRI
Abstract: This thesis aimed to investigate the neurobiological mechanisms of adolescent onset depression and anxiety disorders. A longitudinal fMRI study design was used that included both task related brain activation and resting state functional connectivity. All participants were scanned three times in a six-month period. In between scan sessions the adolescents from the clinical group received treatment as usual. Adolescents from the control group were scanned within the same time interval but did not receive treatment. During a scan session several MRI parameters were collected including task based fMRI (emotional face processing task) and resting state fMRI. We also administered several questionnaires about derpession and anxiety symptomatology. It was demonstrated that adolescents with depressive and anxiety disorders show differentiating patterns of amygdala reactivity and connectivity compared to a healthy control group. Furthermore, using a dimensional approach and taking individual differences in self-reported depression and anxiety symptoms into account highlighted the role of self-reported anxiety symptoms in amygdala reactivity during emotional faces processing. These findings indicate that the amygdala indeed is an important region involved in emotional face processing and that focusing on this region can provide further insights in the development and persistence of depressive and anxiety disorders in adolescents.
Description: Promotores: R.R.J.M. Vermeiren, E.A. Crone
With Summary in Dutch
Faculty: LUMC
Citation: Bulk, B.G. van den, 2015, Doctoral Thesis, Leiden University
ISBN: 9789064648748
Handle: http://hdl.handle.net/1887/33130
 

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