On longevity and the aging process : a magnetic resonance imaging study of the brain

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On longevity and the aging process : a magnetic resonance imaging study of the brain

Type: Doctoral Thesis
Title: On longevity and the aging process : a magnetic resonance imaging study of the brain
Author: Altmann-Schneider, Irmhild
Publisher: Department of Radiology, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2015-05-26
Keywords: Human familial longevity
Senescence
Magnetic resonance imaging
Neuroimaging
Abstract: The aim of this thesis was to investigate the radiological phenotype of the human brain in familial longevity with regard to brain structure. This study was performed as part of the Leiden Longevity Study – a study population consisting of offspring of long-lived Dutch people who are genetically predisposed to become long-lived as well and their environmentally and age-matched spouses. Dedicated MR imaging techniques were applied to study the phenotype of the human brain on the macrostructural as well as microstructural level. Both features which are most likely caused by early development and a lower susceptibility to known age-related structural brain changes on the macro- as well as microstructural level are hallmarks of the brain phenotype in longevity. The contributing mechanisms have yet to be identified but may involve homeostatic control and body function. Keeping in mind that there is a gradual transition from healthy brain aging to what is generally accepted as “normal” brain aging and pathological brain changes as disease correlates, our study results implicate that the brains of offspring of nonagenarian siblings are less susceptible to neurodegenerative brain changes such as (vascular) dementia, Alzheimer’s disease and cerebrovascular disease. Our findings should be considered as starting points for future studies on the functional implications of the presented results and studies on the underlying pathways of brain structure preservation in human longevity.
Description: Promotores: M.A. van Buchem, R.G.J. Westendorp, Co-Promotores: J. van der Grond, A.J.M. de Craen
With Summary in Dutch
With Summary in German
Faculty: LUMC
Citation: Altmann-Schneider, I., 2015, Doctoral Thesis, Leiden University
ISBN: 9789490858360
Handle: http://hdl.handle.net/1887/33073
 

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application/pdf Part I: Chapter 2 404.8Kb View/Open Full text at publisher site
application/pdf Part I: Chapter 3 371.5Kb View/Open Full text at publisher site
application/pdf Part I: Chapter 4 624.8Kb View/Open Full text at publisher site
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application/pdf Part II: Chapter 6 518.4Kb View/Open
application/pdf Part II: Chapter 7 427.9Kb View/Open Full text at publisher site
application/pdf Summary in English 197.0Kb View/Open
application/pdf Summary in Dutch 204.0Kb View/Open
application/pdf Summary in German 207.1Kb View/Open
application/pdf References_Publications_Curriculum Vitae 266.2Kb View/Open
application/pdf Propositions 245.5Kb View/Open

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