Studies into epigenetic variation and its contribution to cardiovascular disease

Leiden Repository

Studies into epigenetic variation and its contribution to cardiovascular disease

Title: Studies into epigenetic variation and its contribution to cardiovascular disease
Author: Talens, Rudolf Pieter
Publisher: Departmen of Molecular Epidemiology, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2015-01-08
Keywords: Epigenic variation
Cardiovascular disease
Epigenetic mechanisms
Cellular gene expression
Abstract: Epigenetic mechanisms regulate cellular gene expression potential without changing the genetic code. Like the genetic sequence, epigenetic marks are faithfully transmitted during mitosis and are generally stable in differentiated cells, but in contrast with the static genome, the epigenome retains the capacity for dynamic changes in each individual cell. Epigenetic variation is therefore a topic of interest for research on ageing and its related common diseases. In this thesis we focus on DNA methylation, which is the most studied layer of epigenetic information,and is correlated to the other epigenetic layers. We used a combination of successive studies to investigate aspects of variation in DNA methylation, various sources generating such variation and its relation with risk for myocardial infarction (MI) at candidate loci for cardiovascular and metabolic diseases
Description: Promotores: P.E. Slagboom, J.W. Jukema, Co-promotor: B.T. Heijmans
With summary in Dutch
Faculty: LUMC
Citation: Talens, R.P., 2015, Doctoral thesis, Leiden University
ISBN: 9789462950481
Handle: http://hdl.handle.net/1887/30776
 

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application/pdf Chapter 1 Intr ... esearch on common diseases 972.9Kb View/Open
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application/pdf Chapter 7 Thes ... and discussion of results 924.1Kb View/Open
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application/pdf Summary in Dutch 247.9Kb View/Open
application/pdf Acknowledgements_Curriculum Vitae_Publications 253.6Kb View/Open
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