Rationally designed peptide based functional biomaterials

Leiden Repository

Rationally designed peptide based functional biomaterials

Title: Rationally designed peptide based functional biomaterials
Author: Zope, Harshal R.
Publisher: Supramolecular & Biomaterials Chemistry Group, Faculty of Science, Leiden University
Issue Date: 2014-12-23
Keywords: Peptides
Coiled coil
Nanoparticles
Biopolymers
Adjuvants
Zebrafish
Biomembrane engineering
Random copolypeptides
Abstract: Nature’s own building block, peptide/protein derived materials have been of great interest for supramolecular chemists. The amino acids in peptides/proteins are linked via amide bonds, which makes them more stable against degradation as compared to other natural materials such as oligonucleotides. Peptides adopt a secondary structure which is determined by their amino acid sequence resulting in a structure with a specific fold like a beta sheet, a helix or a random coil conformation.These secondary structures can govern the supra-molecular structure of the macromolecule to achieve specific function. Peptides can be short, such as dipeptides or as long as a small protein, which are able to selfassemble into a designed nanostructure and thus providing a wide choice of biomaterials for a chemical biologist. In last decade, peptides have been shown to have great versatility and inherent high affinity for their target to carry out various functions which is the scope of this thesis presented here.
Description: Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros
With summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Zope, H.R., 2014, Doctoral thesis, Leiden University
ISBN: 9788360391334
Handle: http://hdl.handle.net/1887/30221
 

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application/pdf Title page_Contents 220.1Kb View/Open
application/pdf Chapter 1 General introduction 270.1Kb View/Open
application/pdf Chapter 2 1.217Mb View/Open
application/pdf Chapter 3 1.383Mb Under embargo Full text at publisher site
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application/pdf Chapter 7 2.379Mb View/Open
application/pdf Chapter 8 Summary and perspective 190.5Kb View/Open
application/pdf Summary in Dutch 200.2Kb View/Open
application/pdf Curriculum Vitae_List of publications 281.3Kb View/Open
application/pdf Propositions 131Kb View/Open

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