Late effects after treatment for Hodgkin lymphoma

Leiden Repository

Late effects after treatment for Hodgkin lymphoma

Title: Late effects after treatment for Hodgkin lymphoma
Author: Daniëls, Laurien Aletta
Publisher: Radiotherapy Division, Department of Clinical Oncology, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2014-10-14
Keywords: Hodgkin lymphoma
Late treatment effects
Cardiac complications
Quality of life
Abstract: Although modern treatment strategies have made Hodgkin Lymphoma (HL) a highly curable disease, there is a life-long increased risk of morbidity and mortality due to treatment. Over time it has become increasingly evident that the historically used extensive treatment fields can potentially lead to numerous long-term adverse effects, often presenting clinically with a delay of more than 10-15 years. Epidemiological studies have shown an increased risks of second malignancies in HL survivors. HL survivors treated with mediastinal radiotherapy also have increased risk of late cardiac complications such as myocardial infarction, which might be due to radiation-induced coronary artery stenosis. All these adverse effects can severely impact health-related quality of life. This thesis investigates the long-term sequelae that HL survivors may encounter. The long-term risk of secondary skin cancers after radiotherapy in HL survivors was evaluated, and compared to the risks in the general Dutch population. The feasibility of screening for coronary artery disease by means of computed tomography coronary angiography (CTA) in HL survivors was investigated, and also satisfaction with information provision and the psychological burden of screening. Furthermore, the prevalence of fatigue in HL survivors compared with the general Dutch population, and associations with predisposing factors were assessed.
Description: Promotor: C.L. Creutzberg, Co-Promotor: A.D.G. Krol
With Summary in Dutch
Faculty: LUMC
Citation: Daniëls, L.A., 2014, Doctoral Thesis, Leiden University
ISBN: 9789462036376
Sponsor: Nederlandse Hartstichting, Elekta BV Nederland, Toshiba Medical Systems Nederland, ABNAMRO, Stichting doelfonds klinische oncologie Bontius
Handle: http://hdl.handle.net/1887/29128
 

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