Schistosoma mansoni and Schistosoma haematobium infection and morbidity in a co-endemic focus: Integrated study of epidemiological, micro-geographical and immunological patterns

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Schistosoma mansoni and Schistosoma haematobium infection and morbidity in a co-endemic focus: Integrated study of epidemiological, micro-geographical and immunological patterns

Title: Schistosoma mansoni and Schistosoma haematobium infection and morbidity in a co-endemic focus: Integrated study of epidemiological, micro-geographical and immunological patterns
Author: Meurs, Lynn
Publisher: Department of Parasitology, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2014-10-09
Keywords: Schistosomiasis
Senegal
Schistosoma haematobium
Schistosoma mansoni
Epidemiology
Cytokine
Co-infection
Morbidity
Abstract: In Africa, polyparasitism is the rule rather than the exception. The aim of this thesis was to get a detailed insight into the micro-geographical distribution and patterns of S. mansoni and S. haematobium co-infections, and how this affects host morbidity. A community-wide study was carried out in a co-endemic focus in the north of Senegal, combining epidemiological, ecological, immunological, and geographical analyses. This multidisciplinary approach led to several new insights. Spatial analyses showed significant clustering of Schistosoma infection and morbidity even on a micro scale; S. mansoni and S. haematobium hotspots were found in different sections of one community. Another major finding was that the presence of S. mansoni in co-infections might protect against S. haematobium-specific urinary tract morbidity. Furthermore, it was observed that S. haematobium antigens induced stronger cytokine responses than those of S. mansoni, indicating that the first species may be more immunogenic. The results of this thesis provide new leads for further research on disease etiology and underlying mechanisms in Schistosoma co-infections. Such knowledge is key to rationalizing and optimizing current schistosomiasis control strategies in co-endemic areas and to developing successful elimination strategies in the future.
Description: Promotores: M.Yazdanbakhsh, M. Coosemans, Co-Promotor: K. Polman
With Summary in Dutch
With Summary in French
Also Dissertation for the degree of Doctor in Biomedical Sciences at the University of Antwerp, Belgium
Faculty: LUMC
Citation: Meurs, L., 2014, Doctoral Thesis, Leiden University
ISBN: 9789053359105
Sponsor: Instituut voor Tropische Geneeskunde Antwerpen European Union's sixth framework programme (INCO-CT-2006-032405)
Handle: http://hdl.handle.net/1887/29089
 

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