Tailoring endocrine treatment for early breast cancer

Leiden Repository

Tailoring endocrine treatment for early breast cancer

Title: Tailoring endocrine treatment for early breast cancer
Author: Fontein, Duveken Berthe Yvonne
Publisher: Department opf Surgery, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2014-10-14
Keywords: Breast cancer, hormonal therapy, endocrine-sensitive, quality of life, sentinel node
Abstract: This thesis describes several important aspects of adjuvant endocrine therapy for postmenopausal women with endocrine-sensitive, early-stage breast cancer. In our ongoing efforts to tailor treatment so as to provide the best possible care to each of our patients, we studied the influence of various tumor- and patient-related factors on outcomes of adjuvant endocrine therapy. These factors include quantitative hormone receptor (HR) expression, body weight, age and physical activity, changes in prognosis over time, quality of life, treatment compliance, treatment-specific side effects, and single nucleotide polymorphisms (SNPs) of the aromatase gene (CYP19A1). In addition, the effect of preoperative (neoadjuvant) endocrine therapy in strong endocrine-sensitive, postmenopausal breast cancer patients is described. Finally, this thesis includes a chapter on the optimal timing of the sentinel lymph node procedure in breast cancer patients treated with neoadjuvant systemic therapy in general. The results of these studies contribute to further individualization of HR-positive early breast cancer and can improve survival outcomes while maintaining a good quality of life.
Description: Promotores: C.J.H. van de Velde, J.W.R. Nortier, Co-promotor: C. Seynaeve
With summary in Dutch
Faculty: LUMC
Citation: Fontein, D.B.Y., 2014, Doctoral thesis, Leiden University
ISBN: 9789082268300
Handle: http://hdl.handle.net/1887/29024
 

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application/pdf Title page_Contents 254.4Kb View/Open
application/pdf Chapter 1 Gener ... and outline of this thesis 183.7Kb View/Open
application/pdf Part I 116.9Kb View/Open
application/pdf Chapter 2 374.6Kb View/Open
application/pdf Chapter 3 475.7Kb View/Open
application/pdf Chapter 4 509.3Kb View/Open
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application/pdf Chapter 7 656.5Kb View/Open
application/pdf Part II 117.1Kb View/Open
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application/pdf Chapter 10 436.1Kb View/Open
application/pdf Chapter 11 436.7Kb View/Open
application/pdf Chapter 12 554.7Kb View/Open
application/pdf Part III 117.1Kb View/Open
application/pdf Chapter 13 447.0Kb View/Open
application/pdf Chapter 14 446.3Kb View/Open
application/pdf Chapter 15 416.4Kb View/Open
application/pdf Chapter 16 General discussion 193.0Kb View/Open
application/pdf Appendices Summ ... ications_Curriculum Vitae 263.1Kb View/Open
application/pdf Propositions 102.4Kb View/Open

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