Glucose metabolism in healthy ageing

Leiden Repository

Glucose metabolism in healthy ageing

Title: Glucose metabolism in healthy ageing
Author: Wijsman, Carolien A.
Publisher: Department Gerontology and Geriatrics, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden university
Issue Date: 2014-10-08
Keywords: Ageing
Glucose
Insulin
Metabolism
Longevity
Abstract: This thesis aims to describe the role of glucose metabolism in human longevity and to translate the results to an intervention aimed at improving health in older age in the general population. In the first part, we describe evidence for enhanced glucose metabolism in long-lived families. Middle-aged individuals predisposed to longevity were characterized by enhande insulin action at the level of the skeletal muscle, lower accumulation of intramyocellular lipids and lower nocturnal glucose levels. These results have provided the biological basis upon which health-promoting intervention in older age may be funded. In the second part, we have shonw that an internet-based intervention is effective at increasing physical activity and improving health in an older population. Furthermore, increasing total daily physical activity in sedentary elderly was shown to lead to better metabolic health.
Description: Promotor: R.G.J. Westendorp, Co-promotor S.P. Mooijaart
With summary in Dutch
Faculty: LUMC
Citation: Wijsman, C.A., 2014, Doctoral thesis, Leiden University
ISBN: 9789090284057
Sponsor: Philips Healthcare Netherlands Consortium for Healthy Ageing (NCHA)
Handle: http://hdl.handle.net/1887/29017
 

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application/pdf Chapter 1 General introduction 391.3Kb View/Open
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