Drug-target residence time : a case for the adenosine A1 and A2A receptors

Leiden Repository

Drug-target residence time : a case for the adenosine A1 and A2A receptors

Title: Drug-target residence time : a case for the adenosine A1 and A2A receptors
Author: Guo, Dong
Publisher: Department of Medical Chemistry, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University
Issue Date: 2014-06-25
Keywords: Binding kinetics
Residence time
GPCR
Adenosine receptor
Kinetic assay
Abstract: Ligand-receptor binding kinetics is increasingly recognized to play a pivotal role in the early phase of drug design and discovery. In this thesis ligand-receptor binding kinetics, particularly residence time, at the adenosine A1 and A2A receptors was extensively investigated. Several case studies at these two prototypical GPCRs demonstrate that binding kinetics as an emerging paradigm can provide additional information of drug-target interactions at the molecular level. This thesis will contribute to stipulating the importance of kientics-based drug design and discovery in the future.
Description: Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
With Summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Guo, D., 2014, Doctoral Thesis, Leiden University
ISBN: 9789461086976
Handle: http://hdl.handle.net/1887/26833
 

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