Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites

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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites

Title: Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Author: Ries, Marco
Publisher: Division of Analytical BioSciences, Faculty of Science, Leiden University
Issue Date: 2014-02-25
Keywords: Metabolomics
Multiple stage fragmentation
Direct-Infusion Mass Spectrometry
Roquefortine biosynthesis
Fungisporin biosynthesis
NRPS
Abstract: This dissertation describes the development and application of new mass spectrometry based tools which were used for the identification of various secondary metabolite pathways present in the fungus Penicillium chrysogenum. Using these tools the biosynthesis of metabolites like roquefortine, meleagrin and fungisporin could be elucidated.
Description: Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken
With summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Ries, M., 2014, Doctoral thesis, Leiden University
Sponsor: This research is supported by the Dutch Technology Foundation STW, which is part of the Netherlands Organisation for Scientific Research (NWO) and partly funded by the Ministry of Economic Affairs (project number 10469).
Handle: http://hdl.handle.net/1887/24303
 

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