Development of immune responses in early life : a longitudinal study in Indonesia

Leiden Repository

Development of immune responses in early life : a longitudinal study in Indonesia

Title: Development of immune responses in early life : a longitudinal study in Indonesia
Author: Djuardi, Yenny
Publisher: Department of Parasitology, Faculty of Medicine / Leiden University Medical Center (LUMC)< Leiden University
Issue Date: 2013-06-12
Keywords: Adaptive immune responses
Cytokines
Early life
Filaria
Gene polymorphisms
Innate immune responses
Parasitic infection
Pregnant mother
TH1
TH2
Abstract: Early childhood is a critical period where the maturation of the immune system occurs while it receives various challenges from the environment shared with the mother. Children growing in an environment rich in micro-organisms and parasites are thought to have a different pattern of immune response compared to those children growing in a more hygienic environment. This difference might contribute to the lower prevalence of allergic and autoimmune disorders in developing countries compared to affluent countries. Within this context, a number of cohort studies mostly performed in developed countries have focused on finding the link between the pattern of immune responses in early life and health outcomes in later life. In this thesis, we studied child’s innate and adaptive responses during the first 4 years of life in a helminth-endemic area in Indonesia
Description: Promotor: M. Yazdanbakhsh, Co-promotores: E. Sartono, T. Supali
With summary in Dutch
Faculty: LUMC
Citation: Djuardi, Y., Doctoral thesis, Leiden University
ISBN: 9789794987797
Sponsor: NWO-WOTRO, EU grant, KNAW
Handle: http://hdl.handle.net/1887/20955
 

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