Misdirection and guidance of regenerating motor axons after experimental nerve injury and repair

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Misdirection and guidance of regenerating motor axons after experimental nerve injury and repair

Title: Misdirection and guidance of regenerating motor axons after experimental nerve injury and repair
Author: Ruiter, Godard de
Publisher: Department of Neurosurgery, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2013-05-21
Keywords: Axonal regeneration
Gene therapy
Nerve conduit
Peripheral nerve lesion and repair
Abstract: Misdirection of regenerating motor axons is one of the factors that can explain the disappointing recovery of function often observed after nerve injury and repair. In the first part of this thesis we quantified misdirection of motor axon regeneration after different types of nerve injury and repair in the rat sciatic nerve model, and we investigated the impact on functional recovery with ankle motion analysis. In the second part of this thesis we investigated two tools to guide regenerating motor axons in vivo: mechanical guidance with multichannel nerve tubes and biological guidance with gene therapy.
Description: Promotor: M.J.A. Malessy, Co-promotor: R.J. Spinner
With summary in Dutch
Faculty: LUMC
Citation: Ruiter, G.de, 2013, Doctoral thesis, Leiden University
ISBN: 9789461917263
Sponsor: Sundt fellowship (Mayo Clinic), Leids Universitair Fonds (LUF), Janneke Fruin-Helb beurs, Stichting Fundatie van de Vrijvrouwe van Renswoude te ‘s Gravenhage, Stichting Mitialto, Stichting Dr. Hendrik Muller’s Vaderlandsch Fonds, Lustra and Jo Keur Fonds
Handle: http://hdl.handle.net/1887/20891
 

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application/pdf Title page_Contents 557.9Kb View/Open
application/pdf Chapter 1 Introduction_Aims and outline 582.5Kb View/Open
application/pdf Part one_Misdirection of motor axon regeneration 521.9Kb View/Open
application/pdf Chapter 2 949.5Kb View/Open
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application/pdf Part two_Guidance of motor axon regeneration 521.6Kb View/Open
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application/pdf Chapter 10 Summary and future directions 766.3Kb View/Open
application/pdf Summary and future directions in Dutch 592.2Kb View/Open
application/pdf Propositons 173.6Kb View/Open

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