Prothrombotic factors and the risk of myocardial infarction and ischaemic stroke in young women : differences similarities and implications

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Prothrombotic factors and the risk of myocardial infarction and ischaemic stroke in young women : differences similarities and implications

Title: Prothrombotic factors and the risk of myocardial infarction and ischaemic stroke in young women : differences similarities and implications
Author: Siegerink, Bob
Publisher: Department of Clinical Epidemiology, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2013-02-05
Keywords: Coagulation
ischaemic stroke
Hypercoagulability
Myocardial infarction
Thrombosis
Women
Young
Abstract: Myocardial infarction and ischaemic stroke are both forms of arterial thrombosis. It is unclear to what extent hypercoagulability is a causal factor of these diseases and whether this effect might be different for myocardial infarction and ischaemic stroke. Several measures of hypercoagulability were investigated in the RATIO study, a nationwide population based case-control study which includes 248 women with myocardial infarction, 203 women with ischaemic stroke and 925 control women, all under 50 years of age. Chapter 2 describes the relationship of a positive family history of arterial thrombosis and the risk of either myocardial infarction or ischaemic stroke. Chapters 3-6 focus on the intrinsic coagulation proteins. Chapters 7-9 describe a genetic approach that focuses on the role of fibrinogen and coagulation factor XIII. Chapter 10 discusses the role of the fibrinolytic capacity, chapter 11 discusses VWF and ADAMTS13, and chapter 12 discusses the risk of myocardial infarction and ischaemic stroke associated with the presence of markers of the antiphospholipid syndrome. Chapter 13 provides a summary and discussion of these results. These results suggest that hypercoagulability is a cause of ischaemic stroke, whereas it does not have a major effect on the risk of myocardial infarction in young women.
Description: Promotores: A. Algra, F.R. Rosendaal
With summary in Dutch
Faculty: LUMC
Citation: Siegerink, B., 2013, Doctoral thesis, Leiden University
ISBN: 9789491030390
Sponsor: The research presented in this thesis was supported by grants from the Netherlands Heart Foundation, The Netherlands, (grant 1997.063, 2001.069 and 2005B060), the Prevention Fund, The Netherlands, (no. 28-2879), and the Leducq Foundation, France, for the development of Transatlantic Networks of Excellence in Cardiovascular Research (grant 04 CVD 02).
Handle: http://hdl.handle.net/1887/20497
 

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