Metabolic risk factors in depressive and anxiety disorders

Leiden Repository

Metabolic risk factors in depressive and anxiety disorders

Title: Metabolic risk factors in depressive and anxiety disorders
Author: Reedt Dortland, Arianne Klaartje Beraldine van
Publisher: Department of Psychiatry, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2012-11-06
Keywords: Depression
Anxiety
Cardiovascular disease
Tricyclic antidepressants
Dyslipidemia
Cholesterol
Obesity
Inflammation
Lifestyle
Autonomic nervous system
Metabolic syndrome
Abstract: The aim of this thesis was to clarify which aspects of depression and anxiety are related to an increased metabolic risk, and which factors contribute to these associations. Taken together, our findings indicate that people with more severe symptoms of depression and anxiety are at particular risk of progressive dyslipidemia and (abdominal) obesity. The higher rates of smoking and systemic inflammation among people with depression or anxiety partially accounted for their adverse metabolic profile. Dysregulations of the autonomic nervous system partly explained why users of tricyclic antidepressants displayed an increased risk of dyslipidemia and (abdominal) obesity as well, and also of hypertension. These important findings shed light on useful avenues for future research, and on preventive and therapeutic insights and directions.
Description: Promotores: F.G. Zitman, B.W.J.H. Pennix, Co-Promotores: E.J. Giltay, T. van Veen
With Summary in Dutch
Faculty: LUMC
Citation: Reedt Dortland, A.K.B. van, 2012, Doctoral Thesis, Leiden University
ISBN: 9789088914898
Handle: http://hdl.handle.net/1887/20090
 

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