Computerised modelling for developmental biology : an exploration with case studies

Leiden Repository

Computerised modelling for developmental biology : an exploration with case studies

Title: Computerised modelling for developmental biology : an exploration with case studies
Author: Bertens, Laura M.F.
Publisher: Research Group Imaging and Bioinformatics, Leiden Institute of Advanced Computer Science (LIACS), Faculty of Science, Leiden University
Issue Date: 2012-09-12
Keywords: bio-informatics, developmental biology, heart development, Petri nets, ontology, Emys orbicularis, gradient formation
Computational modelling
Developmental biology
Emys orbicularis
Gradient formation
Heart development
Petri nets
Abstract: Many studies in developmental biology rely on the construction and analysis of models. This research presents a broad view of modelling approaches for developmental biology, with a focus on computational methods. An overview of modelling techniques is given, followed by several case studies. Using 3D reconstructions, the heart development of the turtle is examined, with special attention to heart looping and the development of the outflow tract. Subsequently, an ontology system is presented in which anatomical, developmental and physiological information on the vertebrate heart is modelled. Finally, two Petri net models are discussed, which model the developmental process of gradient formation, both in a qualitative and quantitative manner.
Description: Promotor: J.N. Kok, Co-promotor: F.J. Verbeek
With summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Bertens, L.M.F., 2012, Doctoral thesis, Leiden University

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application/pdf Bibliography 219.2Kb View/Open
application/pdf Summary in Dutch 170.1Kb View/Open
application/pdf Publications_Curriculum Vitae_Acknowledgements 167.1Kb View/Open
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