Photic and non-photic modulation of the mammalian circadian clock

Leiden Repository

Photic and non-photic modulation of the mammalian circadian clock

Title: Photic and non-photic modulation of the mammalian circadian clock
Author: Oosterhout, Floortje Francisca Theodora Odilia van
Publisher: Faculty of Medicine / Leiden university Medical Center (LUMC), Leiden University
Issue Date: 2012-01-12
Keywords: Circadian
Circadian clock
Non-photic modulation
Ultraviolet light
Abstract: Throughout the animal kingdom, species have evolved an internal time-keeping system, referred to as a 'biological clock'. This internal clock allows anticipation to profound, but largely predictable, environmental day-night changes on earth. The biological clock drives 24h-rhythms in physiology and behaviour, and aligns the endogenous rhythms to the external solar day in a close temporal relationship. Being in synchrony with the environmental light-dark cycle allows the organism to cope adequately with daily changes in food availability, ambient temperature, the presence of predators, mating opportunities and/or social interactions. Additionally, the biological timing system has a major function in the regulation of seasonal rhythms, for instance in reproduction, animal migration and fur change. In order to be of functional use, the biological clock needs to be adjusted to the 24h cycle of the environment on a daily basis. The most important stimulus to regulate the synchronisation is light, which is detected via specialized eye pigments. Apart from light (photic stimulus), the biological clock is also responsive to non-photic stimuli, such as behavioural activity and pharmacological agents. The research described in this thesis examines how photic and non-photic cues modulate the activity of the biological clock.
Description: Promotor: J.H. Meijer
With summary in Dutch
Faculty: LUMC
Citation: Oosterhout, F.F.T.O. van, 2012, Doctoral thesis, Leiden University
ISBN: 9789081844604

Files in this item

Description Size View
application/pdf Cover 4.641Mb View/Open
application/pdf Title page_Contents 37.52Kb View/Open
application/pdf Chapter 1 Introduction 3.177Mb View/Open
application/pdf Chapter 2 2.265Mb View/Open
application/pdf Chapter 3 2.206Mb View/Open
application/pdf Chapter 4 2.281Mb View/Open
application/pdf Chapter 5 1.078Mb View/Open
application/pdf Chapter 6 530.8Kb View/Open
application/pdf Chapter 7 Discussion_Conclusions and implications 259.2Kb View/Open
application/pdf Summary_Summary in Dutch 152.1Kb View/Open
application/pdf List of publica ... edgements_Curriculum Vitae 117.1Kb View/Open
application/pdf Propositions 27.23Kb View/Open

This item appears in the following Collection(s)