Pharmacologic and clinical aspects of isolated hepatic perfusion (IHP) of liver metastases of solid tumours

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Pharmacologic and clinical aspects of isolated hepatic perfusion (IHP) of liver metastases of solid tumours

Title: Pharmacologic and clinical aspects of isolated hepatic perfusion (IHP) of liver metastases of solid tumours
Author: Iersel, Liselot van
Publisher: Department of Clinical Oncology and Department of Surgery, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2011-12-13
Keywords: Isolated hepatic perfusion
Melphalan
Oxaliplatin
Colorectal cancer
Abstract: Isolated hepatic perfusion (IHP) involves complete vascular isolation of the liver to allow local treatment of the liver. During this procedure the blood circulation of the liver is temporarily isolated from the systemic circulation. Although IHP made a promising start in the early 90s, currently it is faced by many challenges. In view of recent developments in systemic treatment, the absence of significant improvement of the technique and the lack of new applicable agents, IHP should not be considered a standard treatment option for colorectal cancer patients with isolated liver metastases. Possibly, a role still exists for IHP in the treatment of liver metastases from non-colorectal cancer origin. Whether under these circumstances, IHP can still attract the interest of both clinical and surgical oncologists necessary for further improvements, remains the question.
Description: Promotores: H. Gelderblom, J.W.R. Nortier, C.J.H. van de Velde, Co-Promotor: P.J.K. Kuppen
With Summary in Dutch
Faculty: LUMC
Citation: Iersel, L. van, 2011, Doctoral Thesis, Leiden University
ISBN: 9789461691651
Sponsor: Bronovo Research Foundation, SKOL, Amgen BV, Novartis Pharma BV, Pfi zer BV, GlaxoSmithKline, Astrazenica BV, Sanofi -aventis BV, MSD BV, Bayer BV, Abbot BV and Roche Nederland BV
Handle: http://hdl.handle.net/1887/18240
 

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