Heterogeneous data analysis for annotation of microRNAs and novel genome assembly

Leiden Repository

Heterogeneous data analysis for annotation of microRNAs and novel genome assembly

Title: Heterogeneous data analysis for annotation of microRNAs and novel genome assembly
Author: Zhang, Yanju
Publisher: Leiden Institute of Advanced Computer Science (LIACS), Faculty of Science, Leiden University
Issue Date: 2011-11-24
Keywords: Carp genome assembly
Gene annotation
Heterogeneous Data Analysis
Innate immune gene
MicroRNA target prediction
Abstract: This thesis is the collection of four published papers demonstrating annotation of genes and microRNAs with the aid of bioinformatics, in particular using heterogeneous data integration. Gene annotation is the process of detecting the structure and biological function of the raw DNA sequences; while microRNA annotation is mainly about identifying its regulatory targets since microRNA modify gene expression by binding to their targets. In order to efficiently and accurately annotate microRNAs and coding region of a novel genome, we developed several complex workflows which integrate the current most relevant data sources and tools. The essence of integration is not to produce even more data but to increase the sensitivity and/or specificity of the algorithm and system. Currently, in life sciences high-throughput experiments, multiple platforms, and multiple model or non-model species are very commonly applied in different studies. In line with this trend heterogeneous data integration is no doubt an important strategy for the analysis of biological data.
Description: Promotor: J.N. Kok, Co-promotor: F.J. Verbeek
With summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Zhang, Y., 2011, Doctoral thesis, Leiden University
ISBN: 9789053354919
Sponsor: This work was part of the BioRange programme of the Netherlands Bioinformatics Centre (NBIC), which is supported by a BSIK grant through the Netherlands Genomics Initiative (NGI).
Handle: http://hdl.handle.net/1887/18145

Files in this item

Description Size View
application/pdf Full text 2.539Mb View/Open
text/html Links to the published articles 8.895Kb View/Open
application/pdf Cover 1.765Mb View/Open
application/pdf Title page_Contents 25.85Kb View/Open
application/pdf Chapter 1 Introduction 451.8Kb View/Open
application/pdf Chapter 2 452.9Kb View/Open
application/pdf Chapter 3 321.0Kb View/Open
application/pdf Chapter 4 326.6Kb View/Open
application/pdf Chapter 5 877.3Kb View/Open
application/pdf Chapter 6 Conclusions 50.25Kb View/Open
application/pdf Summary 40.73Kb View/Open
application/pdf Summary in Dutch 42.42Kb View/Open
application/pdf List of publica ... lum Vitae_Acknowledgements 38.76Kb View/Open
application/pdf Propositions 18.74Kb View/Open

This item appears in the following Collection(s)