Heterogeneous data analysis for annotation of microRNAs and novel genome assembly

Leiden Repository

Heterogeneous data analysis for annotation of microRNAs and novel genome assembly

Title: Heterogeneous data analysis for annotation of microRNAs and novel genome assembly
Author: Zhang, Yanju
Publisher: Leiden Institute of Advanced Computer Science (LIACS), Faculty of Science, Leiden University
Issue Date: 2011-11-24
Keywords: Carp genome assembly
Gene annotation
Heterogeneous Data Analysis
Innate immune gene
Integration
MicroRNA target prediction
Abstract: This thesis is the collection of four published papers demonstrating annotation of genes and microRNAs with the aid of bioinformatics, in particular using heterogeneous data integration. Gene annotation is the process of detecting the structure and biological function of the raw DNA sequences; while microRNA annotation is mainly about identifying its regulatory targets since microRNA modify gene expression by binding to their targets. In order to efficiently and accurately annotate microRNAs and coding region of a novel genome, we developed several complex workflows which integrate the current most relevant data sources and tools. The essence of integration is not to produce even more data but to increase the sensitivity and/or specificity of the algorithm and system. Currently, in life sciences high-throughput experiments, multiple platforms, and multiple model or non-model species are very commonly applied in different studies. In line with this trend heterogeneous data integration is no doubt an important strategy for the analysis of biological data.
Description: Promotor: J.N. Kok, Co-promotor: F.J. Verbeek
With summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Zhang, Y., 2011, Doctoral thesis, Leiden University
ISBN: 9789053354919
Sponsor: This work was part of the BioRange programme of the Netherlands Bioinformatics Centre (NBIC), which is supported by a BSIK grant through the Netherlands Genomics Initiative (NGI).
Handle: http://hdl.handle.net/1887/18145
 

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