Hydrogel based drug carriers for controlled release of hydrophobic drugs and proteins

Leiden Repository

Hydrogel based drug carriers for controlled release of hydrophobic drugs and proteins

Type: Doctoral Thesis
Title: Hydrogel based drug carriers for controlled release of hydrophobic drugs and proteins
Author: Ke Peng
Publisher: Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
Issue Date: 2011-09-14
Keywords: Controlled release
Drug delivery
Hydrogel
Hydrophobic drug
Light sensitivity
Protein
Abstract: The aim of this study is to prepare in situ forming hydrogels based on biocompatible polymers for the controlled release of hydrophobic drug and proteins. In order to load hydrophobic drug to the hydrophilic hydrogel matrix, beta-cyclodextrin and human serum albumin was introduced to the hydrogel network respectively and acted as the primary accommodation for those hydrophobic molecules within the hydrogel network. Furthermore, supramolecular crosslinked and covalently crosslinked light sensitive hydrogels were prepared whose potential application for light controlled protein release system has been shown.
Description: Promotor: Johannes G.E.M. Fraaije, Co-promotor: Alexander Kros
With summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Peng, K., 2011, Doctoral thesis, Leiden University
ISBN: 9789085707820
Handle: http://hdl.handle.net/1887/17833
 

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application/pdf Cover 517.2Kb View/Open
application/pdf Title page_Contents 31.52Kb View/Open
application/pdf Chapter 1 General introduction 43.57Kb View/Open
application/pdf Chapter 2 1.024Mb View/Open Full text at publisher site
application/pdf Chapter 3 2.258Mb View/Open Full text at publisher site
application/pdf Chapter 4 1.551Mb View/Open
application/pdf Chapter 5 689.5Kb View/Open Full text at publisher site
application/pdf Chapter 6 967.5Kb View/Open Full text at publisher site
application/pdf Chapter 7 Summary and perspectives 44.15Kb View/Open
application/pdf Appendix A Summary in Dutch 48.39Kb View/Open
application/pdf Appendix B Curriculum Vitae_List of publications 27.08Kb View/Open
application/pdf Appendix C Acknowledgements 20.46Kb View/Open
application/pdf Appendix D The ... ldithio) propionate (SPDP) 50.38Kb View/Open

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