Disease models in vertebrates : from hypoxia to cancer

Leiden Repository

Disease models in vertebrates : from hypoxia to cancer

Type: Doctoral Thesis
Title: Disease models in vertebrates : from hypoxia to cancer
Author: Santos Marques, Inês João dos
Publisher: Institute of Biology, Faculty of Science, Leiden University
Issue Date: 2011-06-29
Keywords: Hypoxia
Pancratic adenocarcinoma
Zebrafish
Retinoic acid receptor antagonist
miR10-a
Metastasis
Abstract: Vertebrates, especially mammals, have long been used as research models in the study of human diseases. During this research we have demonstrated the usefulness of a relatively new animal model, the zebrafish, in understanding human disease formation, progression and even treatment. We first analysed the impact that exposure to constant chronic hypoxia has in the zebrafish heart, both at the morphological and genetic levels. On chapters three and four we demonstrated the worth of the zebrafish larvae in understanding metastasis formation and progression. Whereas in chapter three we focused on the use of the zebrafish as a model to rapidly test the metastatic behaviour of human pancreatic cancer cell lines and primary human tumours; on chapter four we researched the role of retinoic acid receptor antagonist, and mir10-a, as a potential new anti-cancer therapy for pancreatic adenocarcinoma.
Description: Promotores : M.K. Richardson, H.P. Spaink
With Summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Santos Marques, I.J. dos, 2011, Doctoral Thesis, Leiden University
Sponsor: Grant from the Portuguese Foundation for Science and Technology (FCT), reference SFRH/BD/27262/2006, financed by the POHP-QREN- tipology 4.1- Advanced Formation, and co-funded by the European Social Fund and national funds from the MCTES
Handle: http://hdl.handle.net/1887/17742
 

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