Quantitative assessment of brain perfusion with magnetic resonance imaging

Leiden Repository

Quantitative assessment of brain perfusion with magnetic resonance imaging

Type: Doctoral Thesis
Title: Quantitative assessment of brain perfusion with magnetic resonance imaging
Author: Bleeker, Egbert Jan Willem
Publisher: C.J. Gorter Center for High Field MRI of the Department of Radiology, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2011-06-01
Keywords: Bolus tracking MRI
Brain perfusion
Dynamic susceptibility contrast
Magnetic resonance imaging
MRI contrast agent
Perfusion MRI
Abstract: This thesis focuses on assessing blood supply to brain tissue using MRI. For Dynamic Susceptibility Contrast-MRI a series of images is acquired during the passage of a bolus contrast agent through the brain up to the point that the contrast agent is equally mixed within the total blood pool. The tissue MR signal holds the hemodynamic information and the cerebral blood flow and volume. A reference or Arterial Input Function (AIF) measurement close to the brain tissue is required to enable quantification of perfusion. A special focus of this thesis lies on how to measure a correct AIF. A correct shape of the AIF is crucial for absolute or even relative perfusion values. A correct peak-height is necessary for absolute perfusion quantification, but an erroneous peak-height in combination with a correct shape of the AIF can still produce correct relative values for cerebral blood flow and volume. Therefore, the first objective should be to measure the correct shape of the AIF, whereas the measurement of the peak-height of the AIF should be considered of secondary importance.
Description: Promotores: A.G. Webb, M.A. van Buchem, Co-promotor: M.J.P. van Osch
With summary in Dutch
Faculty: LUMC
Citation: Bleeker, E.J.W., 2011, Doctoral thesis, Leiden University
ISBN: 9789461690548
Sponsor: Financial support for publication of this thesis was generously provided by: Philips Healthcare, Stichting Bazis, Stichting Imago, J.E.Jurriaanse Stichting, Guerbet Nederland BV, Bayer BV, Toshiba and Medrad Europe BV.
Handle: http://hdl.handle.net/1887/17680
 

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