Extending the self-assembly of coiled-coil hybrids

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Extending the self-assembly of coiled-coil hybrids

Type: Doctoral Thesis
Title: Extending the self-assembly of coiled-coil hybrids
Author: Robson Marsden, Hana
Publisher: Faculty of Science, Leiden University
Issue Date: 2009-12-09
Keywords: Amphiphiles
Coiled coils
Membrane fusion
Supramolecular chemistry
Abstract: Of the various biomolecular building blocks in use in nature, coiled-coil forming peptides are amongst those with the most potential as building blocks for the synthetic self-assembly of nanostructures. Native coiled coils have the ability to function in, and influence, complex systems composed of multiple building blocks. However, there have only been a limited number of synthetic coiled-coil assemblies that mimic native coiled coils by incorporating multiple assembling components. This thesis represents efforts at extending this aspect of coiled-coil self-assembly. In order to achieve this, a range of hybrid molecules were synthesized which combine coiled-coil peptides with a hydrophobic component. In this way the highly specific coiled-coil self-assembly is juxtaposed with the non-specific, but structure-inducing aggregation of the hydrophobic section. This thesis asked simple questions: can coiled coils function when covalently attached to large hydrophobic blocks? How large can the hydrophobic blocks be? Can coiled coils function when incorporated noncovalently with a supramolecular assembly? By answering these fundamental questions the possibilities of prescriptive self-assembly have been probed and expanded, novel preparative methods have been developed, and specific applications have arisen.
Description: Promotor: J.G.E.M. Fraaije, Co-promotor: A. Kros
With summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Robson Marsden, H., 2009, Doctoral thesis, Leiden University
ISBN: 9789090248967
Handle: http://hdl.handle.net/1887/14498

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