Precision medicine using pharmacogenomic panel testing

Leiden Repository

Precision medicine using pharmacogenomic panel testing

Type: Doctoral Thesis
Title: Precision medicine using pharmacogenomic panel testing
Author: Wouden, C.H. van der
Issue Date: 2020-09-02
Keywords: Pharmacogenomics
Pharmacogenetics
Panel testing
Adverse drug events
Adverse drug reactions
Precision medicine
Personalised medicine
Cost-effectiveness
Clinical trial
Implementation
Abstract: Pharmacogenomics (PGx) utilizes an individual’s germline genetic profile to identify those who are at higher risk for ADRs or lack of efficacy. This information can be used by healthcare professionals (HCPs) to guide dose and drug selection before drug initiation in an effort to optimize drug therapy through precision medicine. Despite both the promise of and the progress in the field of PGx to achieve precision medicine, it is still not routinely applied in patient care. As such, a number of barriers preventing implementation have been identified. These include the undetermined model for delivering PGx, the lack of evidence supporting a PGx panel approach and the lack of tools supporting implementation. Therefore, the work of this thesis aims to support the implementation of precision medicine using PGx panel testing. It reports on generating evidence for PGx panel testing (Part I) and the development of tools facilitating implementation (Part II), evaluates the implementation process utilizing these tools (Part III) and quantifies the impact of PGx implementation on patient outcomes and cost-effectiveness (Part IV).
Promotor: Supervisor: Guchelaar H.-J. Co-Supervisor: Swen J.J.
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden University
Uri: urn:isbn:9789464023749
Handle: http://hdl.handle.net/1887/136094
 

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application/pdf Full text 128.8Mb Under embargo
application/pdf Cover 303.2Kb View/Open
application/pdf Title Pages_Contents 400.6Kb View/Open
application/pdf Chapter 1 4.414Mb View/Open
application/pdf Part I: Chapter 2 16.68Mb View/Open Full text at publisher site
application/pdf Part I: Chapter 3 11.17Mb Under embargo until 2021-02-01 Full text at publisher site
application/pdf Part II: Chapter 4 9.757Mb View/Open Full text at publisher site
application/pdf Part II: Chapter 5 7.214Mb View/Open Full text at publisher site
application/pdf Part III: Chapter 6 15.38Mb Under embargo Full text at publisher site
application/pdf Part III: Chapter 7 10.09Mb View/Open Full text at publisher site
application/pdf Part III: Chapter 8 7.044Mb View/Open Full text at publisher site
application/pdf Part IV: Chapter 9 9.257Mb Under embargo until 2021-09-03
application/pdf Chapter 10 15.88Mb View/Open
application/pdf Chapter 11 3.075Mb View/Open
application/pdf Summary in Dutch 7.981Mb View/Open
application/pdf List of publica ... lum vitae_Acknowledgements 7.331Mb View/Open
application/pdf Propositions 175.9Kb View/Open

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