The interplay between cholesterol and inflammation in the evolution of atherosclerosis

Leiden Repository

The interplay between cholesterol and inflammation in the evolution of atherosclerosis

Type: Doctoral Thesis
Title: The interplay between cholesterol and inflammation in the evolution of atherosclerosis
Author: Verschuren, Laurens
Publisher: Department Vascular and Metabolic Diseases (TNO-KvL )
Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2009-01-22
Keywords: Atherosclerosis
Cholesterol
Inflammation
Mice
Abstract: Atherosclerosis is a multifactorial disease of the large arteries and the leading cause of morbidity and mortality in industrialized countries. There is ample evidence that hypercholesterolemia (i.e. elevated plasma levels apo-B-containing lipoproteins) is a major causative factor in atherogenesis. It is equally clear that atherogenesis has an inflammatory component which is thought to drive the progression of the disease. However, while the lipid component in atherosclerosis development is relatively well-understood, the origin and exact contribution of the inflammatory component remains largely unknown. The aim of this thesis is to further define and delineate the contribution of the inflammatory component to the atherosclerotic process and to elucidate the link between cholesterol and inflammation in atherosclerotic lesion formation and progression. The studies of this thesis show that, besides plasma cholesterol, inflammation contributes to a substantial extent to atherogenesis. Intervention strategies directed at lowering apoB-containing lipoproteins and reducing inflammation may therefore be more effective than current lipid-lowering strategies. Direct experimental evidence for this assumption mainly comes from animal experiments as described in this thesis. Human intervention studies are necessary to evaluate whether these findings can also be translated to the human situation.
Description: Promotor: J.H. van Bockel, Co-promotores: R. Kleemann, T. Kooistra
With summary in Dutch
Faculty: LUMC
Citation: Verschuren, L, 2009, Doctoral thesis, Leiden University
ISBN: 9789071382819
Sponsor: The research described in this thesis was supported by a grant of the Netherlands Heart Foundation (NHF-2002B102)
Handle: http://hdl.handle.net/1887/13415
 

Files in this item

Description Size View
application/pdf Cover 150.3Kb View/Open
application/pdf Title page and contents 87.47Kb View/Open
application/pdf Chapter 1 392.4Kb View/Open
application/pdf Chapter 2 1.041Mb View/Open Full text at publisher site
application/pdf Chapter 3 328.2Kb View/Open Full text at publisher site
application/pdf Chapter 4 429.5Kb View/Open Full text at publisher site
application/pdf Chapter 5 219.8Kb View/Open Full text at publisher site
application/pdf Chapter 6 3.564Mb View/Open Full text at publisher site
application/pdf Chapter 7 3.540Mb View/Open
application/pdf Chapter 8 4.122Mb View/Open Full text at publisher site
application/pdf Chapter 9 161.9Kb View/Open
application/pdf List of Publications 86.85Kb View/Open
application/pdf Summary in Dutch 107.0Kb View/Open
application/pdf Curriculum Vitae 52.35Kb View/Open
application/pdf Propositions 51.39Kb View/Open

This item appears in the following Collection(s)