Pathogenesis and treatment of skeletal metastasis : studies in animal models

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Pathogenesis and treatment of skeletal metastasis : studies in animal models

Type: Doctoral Thesis
Title: Pathogenesis and treatment of skeletal metastasis : studies in animal models
Author: Buijs, Jeroen Theodorus
Publisher: Department Endocrinology and Metabolism, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2009-01-21
Keywords: Bmp7
Bone
Bone metastasis
Breast cancer
Prostate cancer
tgf-beta bmp
Abstract: The skeleton is one of the most common organs to be affected by metastatic disease. However, only a restricted number of solid cancers, especially those of the breast and prostate, are responsible for the majority of the bone metastases. Bone metastases are a major cause of morbidity, characterized by severe pain and high incidence of fractures, spinal cord compression and bone marrow aplasia requiring hospitalization. Despite the high frequency of skeletal metastases, the molecular mechanisms underlying the predisposition for tumors to colonize bone are poorly understood and treatment options are often unsatisfactory. The focus of this thesis was to better understand the processes that contribute to the formation of distant metastasis (chapter 2), particularly to bone (chapter 4–7), as well as to explore new treatment strategies with conventional (chapter 4 and 5) and novel therapeutic molecules (chapter 6 and 7) using optical imaging to sensitively monitor growth, dissemination and metastasis in mouse models (chapter 3–7).
Description: Promotor: S.E. Papapoulos, Co-promotor: G. van der Pluijm
With summary in Dutch
Faculty: LUMC
Citation: Buijs, J.T., 2009, Doctoral thesis, Leiden University
ISBN: 9789090236841
Handle: http://hdl.handle.net/1887/13413
 

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